Viomycin Pharmacological Actions on Myoneural Junction Ganglionic Synapse and Smooth Muscle

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Abstract
Viomycin like streptomycin, neomycin and kanamy-cin produces neuromuscular and ganglionic blockade as well as smooth muscle depression. Cochleotoxicity and the pharmacological actions on myoneural junction, ganglionic synpase and smooth muscle strongly suggest that some component of the viomycin molecule must be structurally related to streptomycin, neomycin and kanamycin. Investigations have shown that the antibiotics produced by actinomycetes, which are devoid of cochleotoxicity, do not exert a neuromuscular blocking action. Therefore, an antibiotic causing a streptomycin-like neuromuscular blockade is expected to exhibit some degree of cochleotoxicity also.

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