The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins
- 1 December 1995
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 25 (12) , 3316-3320
- https://doi.org/10.1002/eji.1830251217
Abstract
Leukocyte adhesion involves the leukocyte-specific integrins CD11a/CD18, CD11b/CD18 and CD11c/CD18, which bind to intercellular adhesion molecules (ICAM). Three ICAM have been described, and are expressed on leukocytes and various other cells, but are absent from red cells. Here, we show that the red cell Landsteiner-Wiener (LW) blood group glycoprotein is an ICAM which binds to the leukocyte-specific integrins. This finding has important implications in red cell physiology.Keywords
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