Ein neuer Zugang zu 2′‐O‐Alkylribonucleosiden und Eigenschaften deren Oligonucleotide
- 22 March 1995
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 78 (2) , 486-504
- https://doi.org/10.1002/hlca.19950780219
Abstract
A New Access to 2′‐O‐Alkylated Ribonucleosides and Properties of 2′‐O‐Alkylated OligoribonucleotidesA general access to 2′‐O‐alkylated ribonucleosides using the key intermediate 5 is presented. The incorporation of 2′‐O‐‘ethyleneglycol’‐ and 2′‐O‐‘glycerol’‐substituted (i.e., 2′‐O‐(2‐hydroxyethyl)‐ and 2′‐O‐(2,3‐dihydroxypropyl)‐substituted) ribonucleosides into oligonucleotides affords a new generation of oligonucleotides with high affinity for RNA, high specificity, and increased nuclease resistance.Keywords
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