CHEMICAL-ANALYSIS OF GLYCOSAMINOGLYCANS INHIBITING DNA-SYNTHESIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 12  (2-3) , 127-146
Abstract
Sulfated glycosaminoglycans having inhibitory activity in cellular and subcellular systems were found in some human tumor tissues. These glycosaminoglycans inhibited DNA synthesis of virus transformed SV40-WIRL-3 cells more efficiently than that of their parent normal WIRL-3 cells. Sulfated glycosaminoglycans from normal human and non-tumor tissues did not inhibit DNA synthesis by virus transformed cells as effectively as DNA synthesis by their normal parent cells.