Blood corticosteroids and anterior pituitary ACTH and cytology of dogs exposed to hypocapnia and/or hypoxemia

Publisher Website
Google Scholar
Abstract
The concentration of 17-hydroxycorticosterone and a corticosterone-like fraction in peripheral venous blood was not elevated significantly following 15- or 30-minute exposure of dogs to hypocapnia induced by hyperventilation, to hypoxemia induced by breathing 5% oxygen, or to the combination of these conditions. Neither were there significant differences between control and exposed animals in ACTH content of anterior pituitary tissue, or in ascorbic acid content of adrenals. Cytological study of sections of anterior pituitaries revealed somewhat greater than normal acidophilia in all dogs, with the greatest acidophilia being observed in the hypocapnic animals. The concentration of 17-hydroxycorticosterone was higher than that of the corticosterone-like fraction, the 17-hydroxycorticosterone to corticosterone-like ratio varying from 1.3:1 to 1.7:1.