Mechanism of Antibiotic Resistance in Mycobacterium intracellulare

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Abstract
The mechanism of resistance of M. intracellulare strain 103 and other clinical isolates to a variety of drugs, including aminoglycoside and peptide antibiotic, was investigated. Enzymatic inactivation of aminoglycoside and peptide antibiotics could not be demonstrated. Ribosomes of the strain were sensitive to the antibiotics. The levels of resistance of strain 103 and other clinical isolates decreased dramatically when the culture medium was changed from Dubos agar to Tween 80-containing agar. These results suggest a permeability barrier as the reason for naturally occurring resistance in M. intracellulare.