Inhibition of human neutrophil chemotaxis and chemiluminescence by amphotericin B

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Abstract
The effect of the antifungal drugs amphotericin B, fluocytosine, miconazole, griseofulvin and nystatin on the chemotatic responsiveness of human neutrophils was studied. Amphotericin B in a concentration of 2 .mu.g/ml inhibited chemotactic responsiveness, and in a concentration of 5 .mu.g/ml it also inhibited chemiluminescence. The inhibition of chemotaxis could be reversed by washing the cells. The other antifungal drugs did not inhibit chemotaxis even in concentrations much higher than those obtained in human serum during treatment.