INDUCTION OF IGE-ISOTYPE SPECIFIC TOLERANCE BY PASSIVE ANTIGENIC-STIMULATION OF THE RESPIRATORY MUCOSA

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 50  (4) , 625-630
Abstract
Repeated exposure of high IgE-responder BN rats to an aerosol of ovalbumin (OVA) induced tolerance which was specific for the antigen and the IgE antibody class. Radiotracer studies with 125I-OVA indicated that inhaled antigen doses in the low microgram range was tolerogenic, the bulk of the inhaled antigen being distributed 2:1 between the gastrointestinal and respiratory tracts. Subsequent gastric intubation studies showed that the gastric component did not contribute to tolerance induction suggesting that antigenic stimulation of the respiratory mucosa was central to this process.