Oligothymidylates Substitues Par Un Derive De L'Acridine en Position 5′, A La Fois En Position 5′ et 3′ Ou Sur Un Phosphate Internucleotidique

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Abstract
Oligothyraidylates covalently linked to an acridine derivative (2-methoxy-6-chloro-9-aminoacridine) have been synthesized by the phosphotriester method in solution. The substitution has been carried out at the 5′ position, both at the 5′ and 3′ positions or on an internucleotidic phosphate. A polymethylene linker was used to tether the acridine derivative via its 9-amino group to the terminal or internucleotidic phosphate.