THE EFFECT OF GLUCAGON ON CARBOHYDRATE METABOLISM IN NORMAL HUMAN BEINGS 1

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Abstract
Glucagon (pancreas hyper-glycemic factor), given intravenously to normal humans prod-duced a rapid rise of arterial and venous glucose concentration and increased A-V glucose difference. No change in blood flow occurred. When given as constant intravenous injection for 2 hours, both arterial and venous glucose concentration rose and A-V difference also rose for 1 hour; thereafer both fell. Hypoglycemic symptoms developed at 2 hours. Serum inorganic P, and alpha amino acid N fell during injection, and ketone bodies did not change. In all these respects the effect of glucagon was indistinguishable from that of glucose producing comparable arterial glucose concentration, and different from pituitary growth hormone. No evidence was found to support the notion that glucagon is diabetogenic.