Kinetic Analysis of the Antidiuretic Action of Vasopressin and Adenosine-3′,5′-Monophosphate *

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Abstract
A volume chamber that permits continuous measurement of the net flow of water across the isolated urinary bladder of the toad was developed and used to characterize the response to vasopressin and adenosine-3''-5''-monoposphate (cyclic AMP). The antidiuretic response to both agents gave the same type of saturation kinetics, consistent with the model previously proposed by Hollander and associates (J. Clin. Invest. 1957, 36, 1059). In view of the strong evidence in support of the cyclic AMP theory of the action of vasopressin, it was puzzling to find that the development of spontaneous resistance to either agent alone did not block a significant response to the other. In addition, vasopressin-induced resistant to vasopressin was almost completely reversible, whereas cyclic AMP-induced resistance to cyclic AMP was not reversible under the conditions of the present studies.

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