THE CREATININE CLEARANCE AS A MEASURE OF GLOMERULAR FILTRATION IN DOGS WITH PARTICULAR REFERENCE TO THE EFFECT OF DIURETIC DRUGS

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Abstract
The creatinine clearance for a given dog, calculated from the normal rate of excretion, is constant, regardless of marked changes in urine volume. After feeding creatinine, the clearance rises and a subsequent fall in the blood concn. of creatinine is accompanied by a fall in the clearance value. At the higher levels of blood creatinine concn. the creatinine clearance parallels the blood concn. The changes in the creatinine clearance, reflecting the changes in the blood concn. of creatinine, bear no relation to changes in the urine volume as influenced by diuretic drugs. These observations [made on 7 dogs] do not support the use of creatinine detns. in the blood and urine as a measure of glomerular filtration.