FAMILIAL PALMOPLANTAR KERATODERMA WITH EPIDERMOLYTIC HYPERKERATOSIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 104  (1) , 38-44
Abstract
Cases (3) of palmo-plantar keratoderma in three different families are reported. Clinical features were those of Thost-Unna''s disease; histo-pathological and ultrastructural aspects resembled those of the epidermolytic hyperkeratosis. The literature, 13 cases within 7 families with the same clinical and histopathological characteristics (though without study of the ultrastructure), was reported. The term, familial palmo-plantar keratoderma with epidermolytic hyperkeratosis, is proposed for those cases of palmo-plantar keratoderma with dominant autosomal transmission and the histopathological aspects of the epidermolytic hyperkeratosis. The relationship of this disease with the nevus unius lateris and the bullous ichtyosiform hyperkeratosis are discussed. All 3 diseases could represent various phenotypical aspects of the same genetic abnormality of the keratinization process.

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