Stimulation by Bradykinin, Angiotensin II, and Carbachol of the Accumulation of Inositol Phosphates in PC‐12 Pheochromocytoma Cells: Differential Effects of Lithium Ions on Inositol Mono‐and Polyphosphates

Publisher Website
Google Scholar
Abstract
Rat PC‐12 pheochromocytoma cells respond to stimulation with bradykinin, angiotensin II, and carbachol with an increased formation of labeled inositol phosphates after preincubation of the cells with [3H]inositol. Li+ potentiates greatly the agonist‐induced increase in amount of nositol mono‐, bis‐, and trisphosphate but not the increase in amount of inositol tetrakisphosphate. Separation of the isomers of inositol trisphosphate shows that the lithium‐induced increase in amount of inositol trisphosphate is due to potentiation evoked by lithium of the accumulation of inositol‐1,3,4‐trisphosphate.

This publication has 45 references indexed in Scilit: