Further Studies of the Response to Secretin and Pancreozymin in Man

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Abstract
A comparison has been made of the patterns of secretion of bicarbonate, trypsin, and bile pigment into the human duodenum in response to various dose rates of secretin alone and in combination with pancreozymin. Pancreozymin increased the output of bicarbonate to levels greater than achieved with secretin alone. High dose rates of secretin delayed and lowered the pancreozymin-induced pancreatic secretion of enzymes and discharge of bile pigment into the duodenum. The different patterns of response to changing absolute and proportional amounts of stimulant hormones must be taken into account when pancreatic exocrine secretory capacity is to be measured.