Immune Response against Hamster Erythrocytes in the Low‐Responder Mouse Strains

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Abstract
Golden hamsters were used as hosts in this work, and mice of various strains as donors of antigens. 1) There were no strain differences in immunogenicity of erythrocytes from C57BL/6, AKR, SL and CF1 mice. 2) Primary intravenous immunization with mouse erythrocytes (MRBC) induced the production of hemolysin plaque‐forming cells (PFC) in a large number, but elicited only in a negligible titer production of 2‐mercaptoethanol‐resistant antibody. 3) 2‐Mercaptoethanol‐resistant antibody was produced more efficiently in hamsters pre‐sensitized with mouse lymph node (MLN) cells rather than those pre‐immunized with MRBC after a booster with MRBC. 4) Numbers of PFC in pre‐sensitized hamsters were three‐times that of the non‐sensitized hamsters after a booster with MRBC, when pre‐sensitization was performed intradermally with a small number of MLN cells. 5) Average diameter of the hemolysin plaques in pre‐sensitized hamsters was one and a half times larger than that in non‐sensitized hamsters. Conclusions agree well with the results in our previous papers that the reversed combination of hosts and antigen donors employed support the concept that certain processes required for delayed hypersensitivity contributed to antibody production under a condition suitable for antibody response.

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