BONE-MARROW IMAGING WITH IN-111 CHLORIDE IN APLASTIC-ANEMIA AND MYELOFIBROSIS - CONCISE COMMUNICATION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (2) , 121-125
Abstract
Patients (29) with aplastic anemia and 11 patients with myelofibrosis were evaluated with 111In Cl bone-marrow imaging, ferrokinetics and bone-marrow core biopsies. There was good correlation between the erythrocyte cellularity of the marrow and the 111In bone-marrow scan grades in most patients. In some, the overall scan grade tended to underestimate the erythroid elements because the core biopsy was taken from the area of the greatest radionuclide concentration on the scan. In patients with aplastic anemia, there was a good correlation between the plasma Fe clearance t1/2 [half time] and the scan grade. Less agreement was found in the comparison between the 59Fe sacral and organ counts and the red-cell Fe utilization. In patients with myelofibrosis, there was poor correlation between the surface counts over the sacrum and the red-cell Fe utilization. Plasma Fe clearances were abnormally short and were unrelated to the transferrin saturation levels. Eighteen patients were studied several times to evaluate their responses to steroid therapy. In all, there was good correlation between the bone-marrow imaging, the erythrocyte cellularity, ferrokinetics and the patient''s response to therapy. 111In bone-marrow imaging is useful both in evaluating marrow erythroid activity and in following the response to therapy in patients with these diseases.