The Serologic Sequelae of an Influenza A-2 Epidemic Modified by Intercurrent Vaccination in an Insular Eskimo Population Group

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Abstract
Summary: An epidemic of Influenza A-2 virus infection occurred in an isolated Eskimo population in November of 1957. This was studied serologically, using pre- and postepidemic sera from 183 of the people involved. Approximately 40% of the population had been given a small dose of A-2 influenza vaccine after onset of the epidemic. The general quantitative serologic reaction found post-epidemically in the vaccinated group was significantly lower than that found in unvaccinated, naturally infected individuals. The data did not prove that intercurrent vaccination prevented infection, but did suggest strongly that it altered the morbidity rate and also that it interfered with serologic response to the epidemic virus.

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