Cholesterol Synthesis Inhibitor Showing Reduction of Lipids and Hormone Antagonism

Open Access

1 September 1970

journal article
research article
Published by Elsevier in The American Journal of Clinical Nutrition

Vol. 23 (9) , 1241-1250
https://doi.org/10.1093/ajcn/23.9.1241

Abstract

The compound, SQ 10,591, lowered plasma cholesterol in rats fed normal or hyperlipemic diets by blocking the biosynthesis of cholesterol between mevalonate and lanosterol. It also reduced serum free fatty acids and triglycerides. In addition to its effect on lipids, SQ 10,591 inhibited the uterotrophic activity of estrogen in mice and inhibited production or release of pituitary gonadotrophins in rats. In mature female rats SQ 10,591 caused an interruption of the estrous cycle.

Keywords

This publication has 24 references indexed in Scilit:

Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968
Displacement of 17 -Estradiol from Uterine Receptor Sites by an Estrogen Antagonist
Experimental Biology and Medicine, 1968
An Inhibitor of Cholesterol Biosynthesis
Nature, 1964
Benzmalecene: Inhibition of Cholesterol Biosynthesis and Hypocholesteremic Effect in Rats
Experimental Biology and Medicine, 1960
γ,γ‐Dimethyl‐allyl‐pyrophosphat und Geranyl‐pyrophosphat, biologische Vorstufen des Squalens Zur Biosynthese der Terpene, VI¹⁾
Angewandte Chemie, 1959
Effects of MER-29, a cholesterol synthesis inhibitor, on mammalian tissue lipides
Archives of Biochemistry and Biophysics, 1959
Specific inhibition of cholesterol biosynthesis by a synthetic compound (MER-29)
Archives of Biochemistry and Biophysics, 1959
Inhibition of Dietary Hypercholesteremia and Atherogenesis in the Chicken by a New Synthetic Compound
Circulation Research, 1958
ENDOCRINE ASPECTS OF CORONARY SCLEROSIS
The Lancet, 1956
Prevention of Plasma Cholesterol Elevation and Atheromatosis in the Cholesterol-Fed Bird by the Administration of Dihydrocholesterol
Circulation, 1953