Hyperglycemia and Hypertriglyceridemia Among Persons with Coronary Heart Disease

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Abstract
Four groups of 19 persons each from Tecumseh, Michigan were selected for study because of the following characteristics: group 1, coronary heart disease and hyperglycemia; group 2, coronary heart disease and normal blood glucose concentrations; group 3, no heart disease and hyperglycemia; group 4, no heart disease and normal blood glucose concentrations. The participants in groups 3 and 4 were selected because their blood glucose concentrations were similar to those of individuals in groups 1 and 2, respectively. Each participant gave a history and had a physical examination, ecg and glucose tolerance test. From fasting blood samples determinations of serum insulin-like activity, cholesterol and triglyceride concentrations and serum lipoprotein electrophoresis were carried out. The 1st group had significantly higher blood glucose and serum triglyceride concentrations than any other group. Hyperglycemia and hypertriglyceridemia tended to occur in the same individuals and this combination of abnormalities appears to be a distinctive feature of 1 segment of the population with coronary heart disease. This biochemical pattern is probably induced by the ingestion of carbohydrate rather than fat. Pre [beta]-lipoprotein bands were detected most frequently among persons with high serum triglyceride concentrations but were no more prevalent among participants with coronary heart disease than among those without heart disease.Authors.