Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development
- 1 December 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 306 (5943) , 551-557
- https://doi.org/10.1038/306551a0
Abstract
Nucleotide sequence and deletion analysis were used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.This publication has 52 references indexed in Scilit:
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