Oral Lesions of Mucous Membrane Pemphigoid: A Study of 85 Cases

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Abstract
Mucous membrane pemphigoid is a relatively rare vesiculobullous disease of mucosal tissues, involving primarily oral and ocular mucous membranes. In all of our 85 cases the oral mucosa was involved, often severely. Oral lesions also preceded lesions in other sites in many patients. Conjunctival involvement was next in frequency with other mucosal sites less commonly involved. Skin lesions were unusual. The most characteristic aspect of the oral involvement is a desquamative form of gingivitis. Other regions of the oral cavity are less commonly involved and the lesions are vesiculobullous in nature rather than desquamative. The histopathology of the oral lesions is that of a nonspecific subepithelial vesiculation with chronic inflammatory infiltration of the corium. Systemic corticosteroids are the most effective method of controlling the inflammatory process. Relatively small doses are adequate for a satisfactory clinical response.

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