ACTION OF TETRAETHYLAMMONIUM ON PRESSOR RESPONSE TO ASPHYXIA

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Abstract
Tetraethylammonium (TEA), which blocks transmission in autonomic ganglia, fails to prevent the pressor response to asphyxia in the dog and rabbit, but does so in the monkey and cat. In the dog the failure of TEA to prevent the pressor response was shown not to be due to failure to prevent the adrenal medullary neurosecretory mechanism (TEA readily blocks this. cholinergic mechanism), nor to participation of skeletal muscular activity (curare alkaloids also fail to prevent the pressure rise), nor to a direct action of asphyxia on ganglion cells and adrenal medulla (TEA fails to block the pressor action of asphyxia of the head). It was concluded that an emergency pressor pathway exists which is either non-ganglionated, or is interrupted by ganglia invulnerable to TEA.

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