Sclerosing Hyaline Necrosis of the Liver in the Chronic Alcoholic

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Abstract
A group of 19 chronic alcoholic patients, with a characteristic clinical syndrome associated with sclerosing hyaline necrosis of the liver, is reported. The clinical features of the syndrome included leukocytosis, fever, abdominal pain, liver enlargement, and tenderness. The pathologic changes responsible for the clinical syndrome are hyaline necrosis of liver cells, infiltration with neutrophils, and an intense sclerosis of the centrolobular sinusoids and veins. Resistant ascites was common in these patients. The prognosis was poor in this highly selected group of patients, as only 4 of the 19 recovered. The prognosis seems to be better in those patients who do not yet have cirrhosis or marked fatty change in the liver.