Macrophage migration inhibition induced by tissue antigen in guinea-pigs.

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  • 1 May 1971
    • journal article
    • Vol. 8  (5) , 791-9
Abstract
Macrophage migration inhibition has been induced with cultures of normal guinea-pig peritoneal exudate cells and mitochondrial antigen of guinea-pig liver. The effect, like the antigen induced phenomenon, is prevented by exposure to trypsin. Puromycin and cycloheximide in contrast did not prevent macrophage migration inhibition. The migration inhibition was compared with the results of skin tests and with passive haemagglutination and immunocyto-adherence tests using liver antigen coated cells. Only the latter test was positive. The migration inhibitory effect is considered in relation to cell-mediated immunity to tissue antigens and its possible role in localization of macrophages in the inflammatory response.