Polyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo.
Open Access
- 1 April 1984
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 4 (4) , 755-760
- https://doi.org/10.1128/mcb.4.4.755
Abstract
The oncogenic potential of polyomavirus in newborn hamsters can be expressed by a recombinant encoding only the middle T protein. However, polyoma middle T requires the cooperation from small T to induce tumors in newborn rats. Similar complementary functions such as cocarcinogens or tumor promotors can be exerted by the simian virus 40 T antigens as well as by one or several products of the early region 1A of adenovirus 2.This publication has 26 references indexed in Scilit:
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