Further evidence for an inhibitor of proliferation elaborated by normal human fibroblasts in culture: Partial characterization of the inhibitor

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Abstract
We present evidence that extends our earlier preliminary report on the stimulatory effect of saline washes on confluent cells in culture (Lacey et al., '77). That work suggested that an inhibitory substance was being removed by the washes. The present work suggests that the inhibitor is in the 10,000–30,000 MW range, is reversibly bound, is cationic and is also a protease inhibitor. It is heat stable, but is apparently degraded with time in our experimental systems.