Effects of a new cholecystokinin antagonist (GE 410) on the smooth muscle of the guinea pig ileum

1 October 1990

journal article
research article
Published by Springer Nature in Cellular and Molecular Life Sciences

Vol. 46 (10) , 1037-1041
https://doi.org/10.1007/bf01940666

Abstract

Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp-β-phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA₂=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [³H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [³H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons.

Keywords

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