Sporothrix schenckiisensitivity to voriconazole, itraconazole and amphotericin B

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Abstract
One hundred clinical isolates of Sporothrix schenckii were tested against voriconazole, itraconazole and amphotericin B using a modification of the NCCLS M27-A in vitro yeast susceptibility testing procedure. NCCLS M38-P for moulds was not used because yeast forms may have been present when the test isolates were incubated at 35 ± 1°C. The minimum inhibitory concentration (MIC) values were: voriconazole 0·5–8 (geometric mean titer 6·50) µg ml-1; itraconazole 0·03–8 (geometric mean titer 1·56) µg ml-1; and amphotericin B 0·25–2 (geometric mean titer 1·23) µg ml-1. The minimum fungicidal concentration (MFC) values were: voriconazole 2–8 (geometric mean titer 7·67) µg ml-1; itraconazole 0·125–8 (geometric mean titer 7·41) µg ml-1; and amphotericin B 0·125–2 (geometric mean titer 1·53) µg ml-1. Based upon MIC values, sensitivity to amphotericin B is strain-dependent. S. schenckii is more sensitive to itraconazole than voriconazole based upon a comparison of MIC geometric means, even though the MIC ranges were essentially the same.

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