FECAL MUTAGENS IN 2 JAPANESE POPULATIONS WITH DIFFERENT COLON CANCER RISKS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (3) , 1164-1169
Abstract
Human feces from 223 Japanese in Hawaii [USA] at high risk for colon cancer and feces from 166 Japanese of northern rural Japan at low risk for colon cancer were shown to contain mutagenic activity under 5 different test conditions. The 1st assay, using the Ames TA98 and TA100 Salmonella test, detected ether-soluble mutagens in the presence and absence of rat liver microsomes. Of these, the TA98 direct-acting mutagens are present more frequently in the feces of the high-risk population than the low-risk population at a high level of statistical significance (P < 0.001). TA98 mutagens activated by rat liver microsomes also occur significantly more frequently in the feces of the Japanese from Hawaii (P < 0.05). Mutagens detected by TA100 in the presence and absence of rat liver microsomes are not commonly found in either Japanese population. The 2nd bacterial test system used to detect fecal mutagens uses Escherichia coli rec-. This system detects water-soluble fecal mutagens which are also present more frequently in the high-risk population than in the low-risk population (P < 0.05).