ESTABLISHMENT OF A CELL-CULTURE LINE FROM A TRANSPLANTABLE RAT STOMACH-CANCER INDUCED BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE
- 1 January 1979
- journal article
- research article
- Vol. 39 (12) , 5141-5146
Abstract
A cell line designated as BV9 was established in culture from a transplantable rat stomach cancer, which was originally induced in the glandular stomach of a Wistar rat by p.o. administration of N-methyl-N''-nitro-N-nitrosoguanidine. The monolayer cells, which were subcultured for more than 35 passages, revealed pleomorphic features. Chromosomal analysis showed hypertetraploidy (mode, 95), and marker chromosomes were present. Cultured cells were injected s.c. into cyclophosphamide-conditioned syngeneic rats and produced tubular adenocarcinomas resembling the original tumor.This publication has 8 references indexed in Scilit:
- Neuroendocrine cells in serially passaged rat stomach cancers induced by MNNGInternational Journal of Cancer, 1979
- Resistance of neoplasms to immunological destruction: role of a macrophage chemotaxis inhibitor.The Journal of Experimental Medicine, 1978
- ESTABLISHMENT OF CULTURED CELL LINES DERIVED FROM A HUMAN GASTRIC CARCINOMA1978
- Adenomatous changes and adenocarcinoma of glandular stomach in Wistar rats induced by N-methyl-N′-nitro-N-nitrosoguanidineVirchows Archiv, 1977
- EFFECT OF CYCLOPHOSPHAMIDE AND OTHER DRUGS ON INCIDENCE OF PULMONARY METASTASES IN MICE1977
- HUMAN CELL LINE (HGC-27) DERIVED FROM METASTATIC LYMPH-NODE OF GASTRIC CANCER1976
- ESTABLISHMENT OF A CELL LINE (CO-115) FROM A HUMAN COLON CARCINOMA TRANSPLANTED INTO NUDE MICE1976
- New Human Tumor Cell LinesPublished by Springer Nature ,1975