A high dose of MPTP overcomes the protective effect of selegiline against dopaminergic neurotoxicity
- 1 July 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 41 (7) , 492-493
- https://doi.org/10.1111/j.2042-7158.1989.tb06509.x
Abstract
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) at 90 mg kg−1 s.c., a dose lethal in non-pretreated mice, was well tolerated in selegiline ((—)-deprenyl)-pretreated mice and produced persistent depletion of striatal dopamine and its metabolites one week after the last of four daily injections. The protective effect of selegiline against dopaminergic neurotoxicity of MPTP can thus be overridden by a high dose of MPTP that would be lethal without selegiline pretreatment.This publication has 12 references indexed in Scilit:
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