FAT MOBILISING EFFECT OF OESTROGENS

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Abstract
Groups of starved rats of both sexes were treated with 3 daily injections of either estradiol benzoate (OB) alone or in combination with testosterone propionate (TP). The effect of these hormones on the concentration of the plasma unesterified fatty acids (UFA) was studied by withdrawing blood daily from the heart. For control conditions, groups of rats were treated with either olive oil, the vehicle of the above hormones, or no injection at all. It was found that estradiol benzoate, 5 mg per dose, caused a mean rise of plasma UFA up to 1376 [plus or minus] 209 [mu]eq/liter; 10 mg OB per dose elevated the mean plasma UFA concentration to 3492 [plus or minus] 246 [mu]eq/liter; and a combination of 5 mg OB + 10 mg TP per dose resulted in a mean plasma UFA concentration of 2379 [plus or minus] 236 [mu]eq/liter. It is concluded that estrogens possess a fat mobilizing property similar to and possibly stronger than that of androgens.

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