RENAL HYPEREMIA IN DOGS INDUCED BY ORAL ADMINISTRATION OF CINCHONA ALKALOIDS

Publisher Website
Google Scholar
Abstract
The effect of oral doses of the sulfates of the cinchona alkaloids on the effective renal plasma flow, as measured by paminohippurate clearances, and the glomerular filtration rate, as measured by creatinine clearances, was studied in dogs. These agents cause an increase in effective renal plasma flow of 30-50% beginning within 30 mins. and lasting for several hrs. according to the sojourn of the drug in the blood. The filtration rate is also increased but to a smaller degree. There is little change in blood pressure but there is usually some acceleration of the pulse rate. The manner of action and possible therapeutic applications are discussed.