An Efficient and Practical Synthesis of l-α-Amino Acids Using (R)-Phenylglycinol as a Chiral Auxiliary
- 1 September 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 65 (9) , 2359-2365
- https://doi.org/10.1246/bcsj.65.2359
Abstract
L-α-Amino acids including L-α-arylglycines were conveniently and stereoselectively synthesized via the α-amino carbonitriles given by the Strecker reaction of (R)-2-amino-2-phenylethanol with aldehydes and hydrogen cyanide. The stereoselectivity of these α-amino carbonitriles was thermodynamically controlled.Keywords
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