Uricase and its action

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Abstract
Several strains of bacteria were found to destroy uric acid. Chloroform and toluene inhibited their action; thymol or 6% methyl alcohol did not. The bacteria grew better and destroyed uric acid at pH 7.4-8.4. When bacteria were killed by toluene, they had no uricolytic action. Minced dog''s liver and kidney kept under aseptic conditions decomposed very little uric acid at 16[degree]; at 38[degree] there was considerable destruction. Shaking the solution while at 38[degree] seemed to increase the destruction. The action was not due to bacteria, as analogous results were obtained in presence of chloroform and toluene. The Felix-glycerol extract retained its activity in presence of toluene.

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