IMMUNE RESPONSE TO INFLUENZA VIRUS .I. EFFECT OF ROUTE AND SCHEDULE OF VACCINATION ON TIME COURSE OF IMMUNE RESPONSE AS MEASURED BY 3 SEROLOGICAL METHODS

  • 1 January 1965
    • journal article
    • research article
    • Vol. 9  (6) , 501-+
Abstract
The influence of the route and schedule of vaccination on the time course of the immune response was studied in groups of rabbits injected with influenza virus antigens. The route and schedule of inoculation determined the maximal level of serum antibody. The routes can be ordered intravenous, intraperitoneal and subcutaneous in decending order of efficiency. Multiple does improved the levels of antibody by all routes, while antigen in Freund''s incomplete adjuvant suppressed the initial response. Changes in the ratios between the 3 tests indicated differences in avidity of antibody produced during the initial and the secondary responses.

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