Acute myoglobinuric renal failure. A consequence of the neuroleptic malignant syndrome

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Abstract
Neuroleptic malignant syndrome and acute myoglobinuric renal failure developed in 3 patients after they had received a combination of a major tranquilizer and a tricyclic antidepressant, or after a large dose of haloperidol. Rhabdomyolysis was demonstrated by biochemical methods as well as by a muscle biopsy. Myoglobinuria was confirmed by radioimmunodiffusion and also was verified in a necropsy specimen. Dehydration and drug interaction with tricyclic antidepressants seemed to be predisposing factors. Renal function recovered when the patient survived the acute episode, but neurologic sequelae persisted. Recommendations that may avert further cases are made.