Effect of Purine Antimetabolites on Serum Globulins in the Rabbit

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Abstract
Ad-ministration of 6-mercaptopurine and 6-thioguanine decreased serum gamma globulin concentrations in rabbits and produced an increase in concentration of a beta-2 protein as measured by agar and paper electrophoresis. Immunoelectrophoretic studies confirmed the increase in the beta-2 globulin and allowed detection of a "gamma-x" precipitin line which was marked by the gamma globulin precipitin line prior to treatment. The data are also consistent with the hypothesis that the effect on antibody producing cells is not limited to suppression of primary response to antigen, but is a continuing effect extending to the mechanisms controlling "normal" gamma globulin levels.

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