PROSTANOIDS IN RABBIT AQUEOUS-HUMOR - EFFECT OF LASER PHOTOCOAGULATION OF THE IRIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 26  (8) , 1087-1092
Abstract
Concentrations of prostanoids (prostaglandin-like-substances) in aqueous humor from normal pigmented rabbit eyes and from those subjected to argon laser photocoagulation of the iris were measured. The predominant prostanoids quantitatively were prostaglandin E2 (PGE2), PGF2.alpha., and PGD2 with minor amounts of 6-keto-PGF1.alpha. and thromboxane B2. In all cases, concentrations of prostanoids in laser-treated eyes were substantially greater than those in normal eyes. This finding was particularly striking in the case of PGE2 which increased 60-fold from 87 pg/ml to 5.5 ng/ml after irradiation. Concentrations of prostanoids following photocoagulation were related to the number of administered laser lesions and prostanoid release was associated with an initial hypertensive response and disruption of the blood-aqueous barrier.