SPECIFICITY OF FC RECEPTOR ON MURINE LYMPHOCYTES FOR IMMUNOGLOBULINS OF IGG AND IGM CLASSES

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 30  (6) , 851-858
Abstract
The Fc receptor for IgG [immunoglobulin G] on lymph node cells recognizes IgG molecules of mouse IgG1, IgG2a and IgG2b subclasses. The presence of an intact CH3 [H chain constant region 3] domain is required to bind IgG to the Fc receptors. While monomeric IgG molecules bind to Fc receptors, heat aggregated IgG was bound more efficiently. The various forms of IgM molecules investigated show only weak or no binding in comparison. The possible biological function of the Fc receptors on lymphocytes is discussed.