The major phenobarbital‐inducible cytochrome P‐450 gene subfamily (P450IIB) mapped to the long arm of human chromosome 19
- 1 May 1988
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 52 (2) , 129-135
- https://doi.org/10.1111/j.1469-1809.1988.tb01088.x
Abstract
We have recently isolated a cloned cDNA that codes for a human orthologue of the major phenobarbital-inducible cytochrome P450IIB subfamily of rodents. The cloned human cDNA was used to analyse, by Southern blot hybridization, DNA extracted from a panel of 9 independent human-rodent somatic cell hybrids. The results indicate that all members of the P450IIB gene subfamily of man are located on chromosome 19. Evidence from hybrids containing different regions of human chromosome 19 localizes this cytochrome P-450 gene subfamily further to the long arm of chromosome 19 in the region cen-q13.3. We propose the designation CYP2B for this locus.Keywords
This publication has 24 references indexed in Scilit:
- Localization of PEPD to the long arm of chromosome 19Annals of Human Genetics, 1987
- The P450 Gene Superfamily: Recommended NomenclatureDNA, 1987
- Linkage between the loci for peptidase D and cytochrome P-450 (CYP1) on chromosome 19Annals of Human Genetics, 1987
- Regional localization of a human cytochrome P-450 (CYP1) to chromosome 19q 13.1?13.3Annals of Human Genetics, 1986
- A cytochrome P‐450 gene family mapped to human chromosome 19Annals of Human Genetics, 1985
- Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probeAnnals of Human Genetics, 1985
- Regulation of expression of liver‐specific enzymesAnnals of Human Genetics, 1982
- Assignment of the human acid α‐glucosidase gene (αGLU) to chromosome 17 using somatic cell hybridsAnnals of Human Genetics, 1979
- Chromosome assignment of some human enzyme loci: mitochondrial malate dehydrogenase to 7, mannosephosphate isomerase and pyruvate kinase to 15 and probably, esterase D to 13Annals of Human Genetics, 1975
- A membrane-filter technique for the detection of complementary DNABiochemical and Biophysical Research Communications, 1966