THE CONTROL OF METHEMOGLOBINEMIA WITH METHYLENE BLUE 12
Open Access
- 1 March 1939
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 18 (2) , 179-185
- https://doi.org/10.1172/jci101033
Abstract
Patients receiving sulfanilamide develop varying degrees of methemoglobinemia, the intensity of which is independent of the amt. of sulfanilamide in the blood. Concs, of methemoglobin ranging from 20 to 40% of the total Hb. occurred in 17 patients whose blood sulfanilamide conc, was less than 10 mg. %. 5 patients, some with higher blood sulfanilamide cones., had over 30% methemoglobin. Intraven. inj. into such individuals of 1 to 2 mg. of methylene blue per kg. body wt. brings about rapid conversion of all of the MHb. to Hb.This publication has 3 references indexed in Scilit:
- A STUDY OF SOME OF THE PHYSIOLOGICAL EFFECTS OF SULFANILAMIDE. II. METHEMOGLOBIN FORMATION AND ITS CONTROLJournal of Clinical Investigation, 1938
- CYANOSIS WITHOUT SULF- OR METHEMOGLOBINEMIA IN PATIENTS RECEIVING SULFANILAMIDE TREATMENTJournal of Clinical Investigation, 1938
- Methaemoglobinaemia due to Sulphanilamide Therapy.1937