Free Radical Formation in a Gamma-irradiated Pyrimidine-purine Co-crystal Complex
- 1 January 1968
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 13 (2) , 101-109
- https://doi.org/10.1080/09553006814550011
Abstract
The formation and properties of free radicals in a co- crystal complex between 1-methylthymine and 9-methyladenine were studied by electron spin resonance spectroscopy. The radicals formed in this complex do not represent a simple composite of those formed in the individual components. For irradiation at 77[degree]K, the location of the radical(s) in the complex could not be determined, but at 300[degree]K radicals are preferentially formed on the 1-methylthymine moiety. The radical on the 1-methylthymine moiety at 300[degree]K is formed by hydrogen addition on C6 of the thymine ring. This radical has greater conformational stability and resistance to heat decay when in the co-crystal complex than when in the 1-methylthymine crystal structure.This publication has 12 references indexed in Scilit:
- FREE RADICALS FORMED BY HYDROGEN ATOM BOMBARDMENT OF THE NUCLEIC-ACID BASESProceedings of the National Academy of Sciences, 1965
- Electron spin resonance of an irradiated single crystal of thymidine.Proceedings of the National Academy of Sciences, 1965
- SOME RADIATION EFFECTS ON DNA AND ITS CONSTITUENTSProceedings of the National Academy of Sciences, 1965
- Electron spin resonance of irradiated DNAPhysics Physique Fizika, 1964
- Crystal Structure of 9-MethyladenineThe Journal of Chemical Physics, 1964
- Quantitative E.S.R.-measurements of Radiation-induced Radicals in NucleotidesInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1964
- Quantitative E.S.R.-measurements of Radiation-induced Radicals in NucleosidesInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1964
- THE CRYSTAL STRUCTURE OF AN INTERMOLECULAR NUCLEOSIDE COMPLEX: ADENOSINE AND 5-BROMOURIDINEProceedings of the National Academy of Sciences, 1963
- The structure of crystals containing a hydrogen-bonded complex of 1-methylthymine and 9-methyladenineActa Crystallographica, 1959
- ELECTRON-SPIN RESONANCE STUDIES OF RADIATION DAMAGE TO THE NUCLEIC ACIDS AND THEIR CONSTITUENTSProceedings of the National Academy of Sciences, 1959