Structure and absolute configuration of pyrophen, a novel pryrone derivative of L‐phenylalanine from Aspergillus niger
- 1 September 1990
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 36 (3) , 292-296
- https://doi.org/10.1111/j.1399-3011.1990.tb00981.x
Abstract
Pyrophen, a novel 4-methoxy-2-pyrone derivative of L-phenylalanine isolated from cultures of Aspergillus niger, crystallizes in the orthorhombic space group P212121, with a = 8.918(1), b = 9.199(3), and c = 18.092(4) .ANG.. The structure was solved by direct methods and the absolute configuration assigned by the Bijvoet method. Refinement gave R = 0.045 and S = 1.78 for 1677 reflections with I > 3.sigma.(I). Though numerous other pyrone natural products are known, including other products of A. niger, this is the first report of an amino acid-pyrone derivative.Keywords
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