Intestinal Infarction in Paroxysmal Nocturnal Hemoglobinuria

Publisher Website
Google Scholar
Abstract
PAROXYSMAL nocturnal hemoglobinuria is an acquired disorder of unknown etiology and diverse manifestations. Most prominent among these, and the feature upon which the diagnosis is made, is the presence of a hemolytic anemia. The anemia, which results from an unknown intracorpuscular abnormality that sensitizes the erythrocytes of the patient to hemolysis in normal human serum,1 varies in severity but can usually be managed successfully with blood transfusions. Fatal complications arise from a tendency to widespread thrombosis. The etiology of this thrombotic tendency is also unclear, but the recently observed increased thrombin generation by plasma from the patients2 may be a . . .