SEVERE BLEEDING DIATHESIS ASSOCIATED WITH INVASIVE ASPERGILLOSIS IN TRANSPLANT PATIENTS

Publisher Website
Google Scholar
Abstract
A severe bleeding disorder developed in 8 renal transplant patients with invasive aspergillosis. The hemorrhagic diathesis was characterized by wound oozing, severe upper and lower gastrointestinal tract hemorrhage, and mucosal bleeding at other sites. This unusual coagulopathy was characterized by a prolonged throbin time, which was corrected with protamine sulfate, and an abnormal Reptilase time. The bleeding disorder antedated the diagnosis of invasive aspergillosis in all cases. The probability that the coagulopathy was due to proteolytic enzymes elaborated by Aspergills sp. is discussed.

This publication has 1 reference indexed in Scilit: