β‐Adrenergic regulation of c‐fos gene expression in an epithelial cell line
- 21 November 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 240 (1-2) , 118-122
- https://doi.org/10.1016/0014-5793(88)80351-x
Abstract
Stimulation of β‐adrenoreceptors in the RSMT‐A5 epithelial cell line is accompanied by an early and transient increase in the expression of the proto‐oncogene c‐fos. Maximal induction was at 30 min, returning to basal levels after 2 h. Similar results were obtained when cells were incubated with 8‐bromo‐cAMP. The induction of c‐fos is specific since the expression of p53, a transformation‐related gene, is not modulated by isoproterenol or 8‐bromo‐cAMP. The increase in c‐fos gene expression is not associated with proliferative activity in these epithelial cells.Keywords
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