Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes
- 12 March 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 262 (1) , 13-16
- https://doi.org/10.1016/0014-5793(90)80141-5
Abstract
We demonstrated that benzyl alcohol, a neutral local anesthetic drug, inhibits the uptake and degradation of lowdensity lipoprotein and endocytosis of transferrin receptors of guinea pig leukemic B lymphocytes (L2C). This inhibition is very rapid, concentration dependant and reversible by simple washing. Membrane fluidity of the living cells is also modified.Keywords
This publication has 14 references indexed in Scilit:
- Modifications of LDL-receptor-mediated endocytosis rates in CEM lymphoblastic cells grown in lipoprotein-depleted fetal calf serumBiochimica et Biophysica Acta (BBA) - Biomembranes, 1989
- Benzyl alcohol increases membrane fluidity and modulates cyclic AMP synthesis in intact renal epithelial cellsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1987
- Effects of benzyl alcohol on enzyme activities and d-glucose transport in kidney brush-border membranesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1986
- Comparison of the internalization efficiency of LDL and transferrin receptors on L2C guinea pig lymphocytesFEBS Letters, 1986
- Characterization of Low Density Lipoprotein Receptors in Freshly Isolated Leukemic Guinea Pig Lymphocytes (L2C)Journal of Receptor Research, 1985
- Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acidsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1981
- Plasma Lipoproteins of Leukemic Guinea Pigs (L2C) Can Regulate Cholesterol Biosynthesis by Lymphocytes of Normal Guinea PigsEuropean Journal of Biochemistry, 1981
- The localisation of small molecules in lipid bilayersFEBS Letters, 1972
- THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJournal of Clinical Investigation, 1955
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949