The Production of Precipitating Antibody in Chickens to a Substance Present in the Fluids of Nonsecretors of Blood Groups A, B and O

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Abstract
Summary: Substances have been isolated from the ovarian cyst of a woman of blood group A who is a nonsecretor of A substance, and from the saliva of a man of group B who is a nonsecretor of B substance. Injection of these materials into chickens resulted in the production of precipitating antibody. The antisera exhibited a specificity for the secretions and derivative substances of A, B and O nonsecretors; there was good correlation between Lea activity of the sample and its ability to precipitate the chicken antisera. It has not, however, proven possible to demonstrate experimentally prepared specific agglutinins for Le(a+) red cells nor can such cells absorb the precipitins from the chicken sera.